Henry Krum Selected Research

Carvedilol (Coreg)

8/2017	Effect of beta-adrenergic blockade with carvedilol on cachexia in severe chronic heart failure: results from the COPERNICUS trial.
6/2016	The β-Blocker to Lower Cardiovascular Dialysis Events (BLOCADE) Feasibility Study: A Randomized Controlled Trial.
4/2010	Differences between beta-blockers in patients with chronic heart failure and chronic obstructive pulmonary disease: a randomized crossover trial.
1/2006	The impact of baseline HR and BP on the tolerability of carvedilol in the elderly: the COLA (Carvedilol Open Label Assessment) II Study.
9/2004	Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial.
5/2004	Tolerability of carvedilol in heart failure: clinical trials experience.
4/2004	Influence of pretreatment systolic blood pressure on the effect of carvedilol in patients with severe chronic heart failure: the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study.
3/2004	NT-proBNP in severe chronic heart failure: rationale, design and preliminary results of the COPERNICUS NT-proBNP substudy.
11/2003	Are beta-blockers as efficacious in patients with diabetes mellitus as in patients without diabetes mellitus who have chronic heart failure? A meta-analysis of large-scale clinical trials.
4/2003	Tolerability of beta-blockers in heart failure: reassurance needed, reassurance provided.

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Henry Krum Research Topics

Disease

179	Heart Failure 10/2021 - 05/2002
66	Hypertension (High Blood Pressure) 01/2018 - 03/2002
41	Myocardial Infarction 01/2020 - 01/2002
35	Fibrosis (Cirrhosis) 01/2020 - 08/2003
24	Systolic Heart Failure 01/2016 - 07/2006
23	Cardiovascular Diseases (Cardiovascular Disease) 10/2021 - 01/2002
19	Hypertrophy 10/2021 - 08/2003
17	Chronic Renal Insufficiency 01/2018 - 02/2007
14	Left Ventricular Dysfunction 01/2020 - 08/2002
12	Cardio-Renal Syndrome 01/2021 - 06/2009
9	Atrial Fibrillation 01/2022 - 05/2010
9	Infarction (Infarctions) 01/2018 - 05/2002
9	Stroke (Strokes) 11/2015 - 03/2009
8	Arthritis (Polyarthritis) 11/2017 - 01/2002
7	Glucose Intolerance 12/2013 - 04/2010
7	Dyspnea (Shortness of Breath) 09/2013 - 07/2005
6	Cardiomegaly (Heart Hypertrophy) 01/2018 - 08/2003
6	Diabetes Mellitus 07/2016 - 11/2003
6	Albuminuria 12/2013 - 12/2009
6	Essential Hypertension 12/2011 - 03/2002
5	Necrosis 03/2019 - 02/2007
5	Type 2 Diabetes Mellitus (MODY) 01/2018 - 12/2010
5	Hypotension (Low Blood Pressure) 01/2017 - 05/2008
5	Diabetic Nephropathies (Diabetic Nephropathy) 12/2013 - 09/2002
5	Liver Diseases (Liver Disease) 07/2011 - 11/2007
4	Rheumatoid Arthritis 11/2017 - 11/2006
4	Osteoarthritis 11/2017 - 11/2006
4	Coronary Artery Disease (Coronary Atherosclerosis) 11/2017 - 02/2007
4	Cardiac Sudden Death (Sudden Cardiac Arrest) 07/2017 - 08/2005
4	Obesity 05/2017 - 12/2011
4	Disease Progression 01/2017 - 01/2003
4	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2014 - 01/2003
4	Diabetic Cardiomyopathies 05/2012 - 11/2007
4	Insulin Resistance 01/2012 - 05/2011
4	Myocardial Ischemia (Ischemic Heart Diseases) 10/2011 - 11/2005
4	Portal Hypertension 07/2011 - 11/2007

Drug/Important Bio-Agent (IBA)

25	Eplerenone (Inspra)FDA LinkGeneric 01/2017 - 10/2002
24	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2019 - 02/2004
21	CollagenIBA 10/2021 - 08/2003
20	Mineralocorticoid Receptor AntagonistsIBA 01/2017 - 10/2002
19	Pharmaceutical PreparationsIBA 01/2017 - 01/2002
18	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2022 - 08/2002
15	urotensin IIIBA 10/2012 - 01/2003
14	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2018 - 05/2002
13	AldosteroneIBA 11/2014 - 10/2002
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2003
12	Carvedilol (Coreg)FDA LinkGeneric 08/2017 - 10/2002
12	Glucose (Dextrose)FDA LinkGeneric 05/2015 - 04/2010
11	Valsartan (Vals)FDA Link 01/2015 - 09/2002
10	Antihypertensive Agents (Antihypertensives)IBA 01/2018 - 10/2002
9	salicylhydroxamic acid (SHAM)IBA 01/2018 - 08/2003
9	DiureticsIBA 01/2017 - 06/2006
9	Peptides (Polypeptides)IBA 10/2012 - 08/2003
8	pro-brain natriuretic peptide (1-76)IBA 01/2019 - 02/2004
8	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2018 - 08/2002
7	Natriuretic PeptidesIBA 01/2018 - 02/2004
7	Neprilysin (Neutral Endopeptidase)IBA 01/2018 - 08/2002
7	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 11/2017 - 03/2005
7	Celecoxib (Celebrex)FDA Link 11/2017 - 01/2002
7	Endothelins (Endothelin)IBA 01/2017 - 03/2002
7	Enalapril FDA LinkGeneric 04/2016 - 08/2002
7	Angiotensin Receptor AntagonistsIBA 12/2015 - 05/2004
7	ReninIBA 05/2013 - 01/2003
7	Bisoprolol (Concor)FDA LinkGeneric 04/2011 - 11/2003
6	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2018 - 09/2002
6	Endothelin Receptors (Endothelin Receptor)IBA 01/2017 - 03/2002
6	Endothelin Receptor AntagonistsIBA 01/2017 - 03/2003
6	Messenger RNA (mRNA)IBA 10/2016 - 11/2005
6	CytokinesIBA 02/2016 - 02/2007
6	AngiotensinsIBA 04/2015 - 01/2005
6	Spironolactone (Aldactone)FDA LinkGeneric 08/2013 - 10/2002
6	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 12/2012 - 01/2002
5	Biomarkers (Surrogate Marker)IBA 05/2017 - 06/2010
5	IndicanIBA 01/2017 - 07/2010
5	Uremic ToxinsIBA 01/2017 - 11/2012
5	aliskiren FDA Link 04/2016 - 09/2010
5	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2016 - 01/2002
5	tranilastIBA 12/2013 - 02/2005
5	Nateglinide (Starlix)FDA LinkGeneric 12/2013 - 04/2010
5	Vasoconstrictor AgentsIBA 02/2013 - 07/2005
5	Diclofenac (SR 38)FDA LinkGeneric 12/2012 - 01/2002
4	PotassiumIBA 01/2022 - 06/2012
4	Digoxin (Digitek)FDA LinkGeneric 01/2022 - 07/2006
4	MAP Kinase Kinase Kinase 5IBA 01/2021 - 01/2017
4	Atrial Natriuretic Factor (ANF)IBA 01/2018 - 01/2012
4	Naproxen (Naprosyn)FDA LinkGeneric 11/2017 - 01/2002
4	Leucine (L-Leucine)FDA Link 01/2017 - 09/2010
4	tezosentanIBA 01/2017 - 03/2003
4	finerenoneIBA 07/2016 - 06/2012
4	Renin InhibitorsIBA 04/2016 - 09/2010
4	EtoricoxibIBA 12/2012 - 11/2006
4	rofecoxib (Vioxx)FDA Link 09/2010 - 01/2002

Therapy/Procedure

100	Therapeutics 01/2022 - 01/2002
27	Denervation 09/2017 - 04/2009
12	Sympathectomy (Sympathectomies) 02/2015 - 04/2009
11	Catheters 07/2014 - 04/2009
9	Drug Therapy (Chemotherapy) 01/2022 - 01/2003
7	Cardiac Resynchronization Therapy 01/2018 - 05/2010
5	Polypharmacy 07/2016 - 07/2005
4	Radiofrequency Ablation 02/2014 - 12/2011